[18F]FMPEP-d2

[18F]FMPEP-d2 is a radiolabeled small molecule used as a positron emission tomography (PET) imaging agent for the cannabinoid subtype 1 receptor (CB1R). It acts as an inverse agonist at CB1 receptors, which are highly expressed in the central nervous system and implicated in various neuropsychiatric and neurodegenerative disorders. The compound was developed to provide high specificity and reduced defluorination compared to earlier tracers by incorporating deuterium atoms into its structure. This modification decreases bone uptake of radioactivity, improving brain imaging quality. [18F]FMPEP-d2 has been used in preclinical and early clinical studies to quantify CB1 receptor density and distribution in the brain, with applications including research on Alzheimer's disease and other neurological conditions[6][7][4][9].

Other names

1059188-91-8UNII-XZ39M85EQBUNII-XZ-39M85EQBUNII-XZ 39M85EQB(3R,5R)-5-(3-((fluoro-18F)methoxy-d2)phenyl)-3-(((1R)-1-phenylethyl)amino)-1-(4-(trifluoromethyl)phenyl)-2-pyrrolidinone